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Title: Executive Function Determinants of Attention-Deficit/Hyperactivity Disorder Medication Response
Author: Kubas, Hanna
Advisor: Hale, James Bradford
Keywords: Educational Psychology
Issue Date: 2-Oct-2013
Abstract: Focusing on behavioural criteria for attention-deficit/hyperactivity disorder (ADHD) diagnosis leads to considerable neuropsychological profile heterogeneity among diagnosed children and variable response to methylphenidate (MPH) treatment. Documenting “cool” executive/working memory (EWM) or “hot” self-regulation (SR)neuropsychological impairments could aid in differential diagnosis of ADHD subtypes and may help determine the optimal MPH treatment dose. In this study, children with ADHD Inattentive Type (n = 18) (IT) and Combined (n = 35)(CT) underwent a randomized double-blind placebo-controlled 4-week MPH trial. Neuropsychological, behavioural, and observational data were collected to evaluate medication response. Results from individual neuropsychological tests suggest that performance was not uniform; those with moderate or significant baseline EWM/SR impairment showed robust MPH response, while response for those with lower baseline executive impairment was minimal. Implications for medication titration, academic achievement, and long-term treatment efficacy were examined.
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