Please use this identifier to cite or link to this item: http://hdl.handle.net/11023/2341
Title: Loop-Mediated Isothermal Amplification for Diagnosis of Major Infectious Diseases in Resource-Limited Settings
Author: Mintchev, Paul
Advisor: van Marle, Guido
Keywords: Engineering--Biomedical
Issue Date: 9-Jul-2015
Abstract: Major Infectious Diseases (MIDs) continue to pose major global health-care challenges in 2015, particularly in resource-limited settings. Alongside the recent global Human Immu-nodeficieny Virus (HIV)/Acquired Immunodeficieny Syndrome (AIDS) pandemic, there has been a marked resurgence in fatalities related to Malaria and Leishmaniasis in Lower-to-Middle-Income Countries (LMICs). With the recent development of Loop-Mediated Isothermal Amplification (LAMP), researchers are hoping to bring rapid and inexpensive point-of-care diagnostics, based on nucleic acid amplification, to LMIC settings. We ex-plored the possibility of a portable, low-cost LAMP-based diagnostic device targeting HIV, Malaria, and Leishmaniasis, for use in resource-limited settings, in an idealized proof-of-concept study. Design and build an inexpensive functional prototype with the potential to quantify disease severity that demonstrates the feasibility of this diagnostic tool for the desired application was the primary outcome; however, much work remains to be done in order to optimize the method to a reliable and repeatable clinical tool.
URI: http://hdl.handle.net/11023/2341
Appears in Collections:Electronic Theses

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