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Title: Brain Development During Childhood and Adolescence
Author: Mah, Alyssa
Advisor: Lebel, Catherine
Keywords: Anatomy;Neuroscience;Human Development;Engineering--Biomedical
Issue Date: 15-Jan-2016
Abstract: Brain development is a combination of complex physiological changes, and various magnetic resonance imaging (MRI) techniques can help explain observed changes during development in vivo. Building upon observations from post-mortem studies, advancements in imaging and modelling techniques provide new means to further interpret the understanding of healthy brain development during childhood and adolescence. It is, however, a challenge to capture specific physiological changes, such as myelination, using MRI. This thesis uses MRI techniques – neurite orientation dispersion and density imaging (NODDI), inhomogenous magnetization transfer (ihMT), and multi-component driven equilibrium single pulse observation of T1 and T2 (mcDESPOT) – that further characterize development in white and subcortical grey matter regions in the brain by improving specificity of the MRI signal compared to conventional techniques. Measures from NODDI, ihMT, and mcDESPOT suggest an increase in myelination and/or axonal packing during development from 0-13 years.
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