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Title: Experience-Dependent Modulation of Adult Hippocampal Neurogenesis in Female Mice
Author: Boon, Jacqueline
Advisor: Dyck, Richard
Keywords: Neuroscience;Mental Health;Pharmacology;Psychology--Experimental
Abstract: The capacity of the mature adult brain to adapt following experience is limited. One means by which the adult brain can undergo plastic change is through the generation of new neurons, a process referred to as neurogenesis. Adult hippocampal neurogenesis (AHN) occurs in the subgranular zone of the dentate gyrus, can be modulated by experience, and has important implications for learning/memory and disease treatment. Experiences rarely occur in isolation and understanding the interacting effects of several modulators is necessary to fully harness potential therapeutic effects of AHN. We examined the combined effects of several modulators including chronic perinatal and adulthood exposure to selective serotonin reuptake inhibitor fluoxetine, social isolation, synaptic zinc and environmental enrichment. Our results emphasize the complexity of modulation of AHN by experience, suggest that synaptic zinc is necessary for the positive modulation of AHN, and imply that this process may be maximally modulated in the hippocampus.
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